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Fig. 6

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ZDB-FIG-230204-19

Publication

Ivica et al., 2021 - Acidic pH reduces agonist efficacy and responses to synaptic-like glycine applications in zebrafish α1 and rat α1β recombinant glycine receptors

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Fig. 6

The effects of acidic pH on the time course of fast agonist responses of zebrafish ?1 GlyR (30 mM intracellular chloride)

Representative macroscopic inward currents elicited by 2 ms concentration pulses of glycine (A) and taurine (B) from outside?out patches held at ?100 mV (?110 mV when corrected for junction potential). Traces are averages of at least five current responses. In the right panels the responses are scaled to their own peak to allow comparison of current kinetics; see also insets. C and D, decay and rise time constants, respectively, for glycine and taurine responses at pH 6.4 (diamonds) and 7.4 (circles). Horizontal line are means and lines connect the measurements from the same patch. Asterisked brackets in C and D denote significance, in paired t tests; for P values see text and Table 4.

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Physiol.