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Fig. 5

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ZDB-FIG-230204-18

Publication

Ivica et al., 2021 - Acidic pH reduces agonist efficacy and responses to synaptic-like glycine applications in zebrafish α1 and rat α1β recombinant glycine receptors

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Fig. 5

Acidic pH reversibly reduces the amplitude of glycine responses of zebrafish α1 GlyR in 30 mM intracellular chloride

A, consecutive current responses recorded from the same outside‐out patch, held at −100 mV, in response to 3 mM 2 ms glycine pulses at pH 7.4 and after pH change to 6.4 (of both the agonist and the control solution; grey traces) and back to 7.4. Responses obtained during the solution exchange in the application tool are marked by a black dashed line above the traces and were not analysed. B, plot of the peak amplitude of the responses shown in the same patch. C, peak amplitudes of glycine responses in patches with recovery. Asterisked brackets denote significance, P = 0.0025 and P = 0.001 when amplitude at pH 6.4 is compared to the preceding or the following pH 7.4 control.

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