FIGURE

Fig. 4

ID

ZDB-FIG-230204-17

Publication

Ivica et al., 2021 - Acidic pH reduces agonist efficacy and responses to synaptic-like glycine applications in zebrafish α1 and rat α1β recombinant glycine receptors

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Fig. 4

Acidification to pH 6.4 reduces the amplitude and changes the time course of outside?out responses of zebrafish ?1 GlyR to fast agonist applications

A, representative inward currents elicited by 2 ms pulses of glycine, ??alanine, taurine and GABA, at pH 7.4 (black) or 6.4 (grey). Traces are averages of at least five current responses and patches were held at ?100 mV. In the right panels the responses are scaled to their peak to allow comparison of current kinetics (see also expanded insets). B, bar chart presenting the peak amplitudes of concentration pulses measured for glycine, alanine, taurine and GABA; error bars show SD, lines connect values from the same patch. C and D, decay and rise time constants, respectively, for currents elicited by the four agonists at pH 7.4 (black) and 6.4 (grey). Horizontal lines are means and lines connect values from the same patch. Asterisked brackets in B, C and D show comparisons that were statistically significant; see Table 3 for P values.

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Physiol.