FIGURE

Fig. 3

ID

ZDB-FIG-230204-16

Publication

Ivica et al., 2021 - Acidic pH reduces agonist efficacy and responses to synaptic-like glycine applications in zebrafish α1 and rat α1β recombinant glycine receptors

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Fig. 3

Acidic pH decreases agonist efficacy but does not affect the conductance of zebrafish ?1 GlyR

A, cluster P _open values produced by saturating agonist concentrations at pH 6.4, 7.4 and 8.4; data at pH 7.4 are from Ivica et al. (2021). Boxes and whiskers show the 25th and 75th and the 5th and 95th percentiles, respectively. The horizontal line in the box is the median. Asterisked brackets denote significance; see text for P values. B, current?voltage relationship for ?1 GlyR single?channel openings at pH 6.4 (grey diamonds) and at pH 7.4 (black squares) recorded from outside?out patches (n = 4 patches, error bars represent SD; the black and the grey lines are fits to the data pooled from four patches at pH 7.4 and 6.4, respectively). C, traces are outside?out recordings from ?1 GlyR in the presence of 10 mM glycine (symmetrical 131.1 mM chloride). Openings are downward and are inward currents, dashed lines indicate closed level

Expression Data

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Physiol.