Fig. 7
- ID
- ZDB-FIG-230204-20
- Publication
- Ivica et al., 2021 - Acidic pH reduces agonist efficacy and responses to synaptic-like glycine applications in zebrafish α1 and rat α1β recombinant glycine receptors
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The effects of acidic pH on responses relevant to native synaptic currents on zebrafish ?1 GlyR and rat ?1? GlyR 10 mM intracellular chloride
The panels on the left show macroscopic inward currents elicited by 3 mM, 2 ms concentration pulses of glycine on homomeric zebrafish ?1 GlyR (A) and heteromeric rat ?1? GlyR (B) recorded in outside?out patches held at a nominal potential of ?100 mV (actual value, ?110 and ?113 mV for experiments with 30 and 10 mM intracellular chloride, respectively). Traces are averages of at least five current responses. C and D, decay and rise time constants, respectively, for glycine and taurine responses at pH 6.4 (diamonds) and 7.4 (circles). Horizontal lines are means and lines connect the measurements from the same patch. Asterisked brackets in C and D denote significance, in paired t tests, for P values see text and Table 4. |