ZFIN Image: Ivica et al., 2021, Fig. 6

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Figure Caption

Fig. 6

The effects of acidic pH on the time course of fast agonist responses of zebrafish ?1 GlyR (30 mM intracellular chloride)

Representative macroscopic inward currents elicited by 2 ms concentration pulses of glycine (A) and taurine (B) from outside?out patches held at ?100 mV (?110 mV when corrected for junction potential). Traces are averages of at least five current responses. In the right panels the responses are scaled to their own peak to allow comparison of current kinetics; see also insets. C and D, decay and rise time constants, respectively, for glycine and taurine responses at pH 6.4 (diamonds) and 7.4 (circles). Horizontal line are means and lines connect the measurements from the same patch. Asterisked brackets in C and D denote significance, in paired t tests; for P values see text and Table 4.

Acknowledgments

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