FIGURE

Fig. 6

ID

ZDB-FIG-221119-40

Publication

Edmister et al., 2021 - A zebrafish model for calcineurin-dependent brain function

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Fig. 6

Fig. 6. Responses to acoustic stimuli. A) Example of one imaging experiment analyzed during the final 40 min in 6-second intervals. B) Habituation to acoustic stimuli at 1-second intervals (first 5 min minus last 5 min of period 17). C) Startle responses (average activity in period 16 minus period 17). D) Excitability by acoustic stimuli at 1 s intervals (average activity in period 17 minus period 16). Larvae were treated at 5 dpf with DMSO (2 μl/mL), cyclosporine (CsA, 10 μM), tacrolimus (FK506, 1 μM), rapamycin (RM, 1 μM), proINDY (5PI = 5 μM proINDY, 10PI = 10 μM proINDY), or a combination of two treatments. Differences between corresponding groups were examined for significance using a Chi-square test with a Bonferroni correction for multiple comparisons. N in panel A = 96 larvae per treatment group. N in panel B, C and D = 912, 372, 188, 263, 383, 275, 190, 178, 93 and 86 larvae in the 10 subsequent treatment groups. * p < 0.05/14), ** p < 0.01/14), *** p < 0.001/14).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Conditions:	chemical treatment by environment: cyclosporin A chemical treatment by environment: tacrolimus (anhydrous) chemical treatment by environment: proINDY chemical treatment by environment: sirolimus
Observed In:	habituation startle response
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Behav. Brain Res.