FIGURE

Fig. 3

ID

ZDB-FIG-221119-37

Publication

Edmister et al., 2021 - A zebrafish model for calcineurin-dependent brain function

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Fig. 3

Fig. 3. Measurements of zebrafish larval behavior. A) Activity in subsequent 10 min periods (18 periods, 3 h total). Cyclosporine (CsA) induced an increase in activity and proINDY (PI) induced a decrease in activity. B) The optomotor response (OMR); zebrafish larvae swim in the same direction as moving lines projected through the bottom of a 96-well plate. Cyclosporine induced a decrease in the optomotor response and proINDY induced an increase in the optomotor response. % move = the percentage of time that larvae move. % up = the percentage of time that a larvae are located in the upper half of a well. The arrowheads indicate the color and direction of the visual stimuli. For example, red lines move down in period 7 and move up in period 8. The red lines in period 13 and 14 move 16x faster than the red, green and blue lines in period 7-12. Blue speaker = acoustic stimuli with a 20-second interval. Yellow speaker = acoustic stimuli with a 1-second interval. Statistical analyses of activity and vision are shown in subsequent figures. N = 912, 372 and 383 larvae in the DMSO vehicle control, cyclosporine and proINDY group, respectively.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Conditions:	chemical treatment by environment: cyclosporin A chemical treatment by environment: proINDY
Observed In:	swimming
Stage:	Day 5

Phenotype Detail

Acknowledgments

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