FIGURE

Figure 2

ID

ZDB-FIG-220801-17

Publication

Gessler et al., 2022 - Control of Directed Cell Migration after Tubular Cell Injury by Nucleotide Signaling

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Figure 2

The involvement of adenosine deaminase family members in zebrafish pronephros repair. (A) In situ hybridization revealed upregulation of zebrafish ada. Depletion of zebrafish ada by a splice—(SBM) blocking morpholino oligonucleotides (MO) delayed the repair process. (B) In situ hybridization revealed upregulation of zebrafish ada2a. Depletion of zebrafish ada2a by a translation- (TBM) blocking morpholino oligonucleotides (MO) had no effect on the repair process. (C) In situ hybridization revealed upregulation of zebrafish ada2b. Depletion of zebrafish ada2b by a TBM delayed the repair process. (D) In situ hybridization revealed upregulation of zebrafish adal. Depletion of zebrafish adal by a TBM had no significant influence on the repair process (mean ± SEM; 2-way ANOVA).

Expression Data

Genes:	ada ada2a ada2b adal
Fish:	WT
Condition:	ablation: pronephros
Anatomical Term:	pronephros
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT WT + MO1-ada WT + MO1-ada2a WT + MO1-ada2b WT + MO1-adal
Condition:	ablation: pronephros
Knockdown Reagents:	MO1-ada MO1-ada2a MO1-ada2b MO1-adal
Observed In:	pronephros pronephros regeneration
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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