Gene

ada2a

ID
ZDB-GENE-030902-4
Name
adenosine deaminase 2a
Symbol
ada2a Nomenclature History
Previous Names
  • ADA2-1 (1)
  • cecr1
  • cecr1a
  • fj65e02
  • wu:fj65e02 (1)
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have several functions, including adenosine deaminase activity; proteoglycan binding activity; and zinc ion binding activity. Predicted to be involved in adenosine catabolic process and inosine biosynthetic process. Predicted to localize to extracellular space. Is expressed in several structures, including cardiovascular system; gill; kidney; liver; and notochord. Human ortholog(s) of this gene implicated in Sneddon syndrome. Orthologous to human ADA2 (adenosine deaminase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ada2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Sneddon syndrome Alliance ?Sneddon syndrome 182410
Vasculitis, autoinflammation, immunodeficiency, and hematologic defects syndrome 615688
Associated With ada2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001365 Adenosine/AMP deaminase domain
Domain IPR013659 Adenosine/AMP deaminase N-terminal
Family IPR006331 Adenosine deaminase-related growth factor
Homologous_superfamily IPR032466 Metal-dependent hydrolase
Domain Details Per Protein
Protein Length Adenosine/AMP deaminase domain Adenosine/AMP deaminase N-terminal Adenosine deaminase-related growth factor Metal-dependent hydrolase
UniProtKB:F1R9S0 503
UniProtKB:P58781 503
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations