FIGURE

Figure 2

ID

ZDB-FIG-220625-2

Publication

Shi et al., 2022 - Characterization of the Interrenal Gland and Sexual Traits Development in cyp17a2-Deficient Zebrafish

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Figure 2

cyp17a2-deficiency caused pituitary pomca upregulation and interrenal gland enlargement in zebrafish larvae. WISH analyses with probes of pomca(A1, A2), cyp11a1(B1, B2), cyp21a2(C1, C2) and hsd3b1(D1, D2) in cyp17a2+/+ and cyp17a2-/- fish at 5 dpf. WISH analyses with probes of pomca(E1–E4), cyp11a1(F1–F4), cyp21a2(G1–G4), and hsd3b1(H1–H4) in fish at 5 dpf. (E1, F1, G1, H1)cyp17a2+/+;pomca+/+ fish. (E2, F2, G2, H2)cyp17a2-/-;pomca+/+ fish. (E3, F3, G3, H3)cyp17a2+/+;pomca-/- fish. (E4, F4, G4, H4)cyp17a2-/-;pomca-/- fish. Black, red, and green arrows indicate normal, enlarged, and decreased interrenal gland, respectively. (I) Bar chart represents the quantification and statistical analyses of WISH signals in pituitary and interrenal gland of fish at 5 dpf. (J1, J2, K1, K2) WISH analysis using the probe of cyp21a2 in cyp17a2+/+ and cyp17a2-/- fish administrated with DMSO or HC from 1 dpf to 5 dpf. (J1, J2) DMSO. (K1, K2) HC. (L) Bar chart represents the quantification and statistical analyses of WISH signals in interrenal gland of fish administrated with DMSO or HC. HC, hydrocortisone. DMSO, dimethyl sulfoxide. n.s., no significant difference. *P < 0.05. **P < 0.01. ***P < 0.001. ****P < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Endocrinol (Lausanne)