Gene
cyp21a2
- ID
- ZDB-GENE-070103-6
- Name
- cytochrome P450, family 21, subfamily A, polypeptide 2
- Symbol
- cyp21a2 Nomenclature History
- Previous Names
-
- cyp21a1 (1)
- si:ch1073-443n13.1
- si:ch211-257p13.4
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable heme binding activity and steroid 21-monooxygenase activity. Acts upstream of or within glucocorticoid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in brain; gonad primordium; head; head kidney; and interrenal primordium. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to human CYP21A2 (cytochrome P450 family 21 subfamily A member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Eachus et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital adrenal hyperplasia | Alliance | Adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency | 201910 |
| congenital adrenal hyperplasia | Alliance | Hyperandrogenism, nonclassic type, due to 21-hydroxylase deficiency | 201910 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9NZM6 | InterPro | 522 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp21a2-201
(1)
|
Ensembl | 1,828 nt | ||
| mRNA |
cyp21a2-202
(1)
|
Ensembl | 3,078 nt | ||
| mRNA |
cyp21a2-203
(1)
|
Ensembl | 3,177 nt | ||
| mRNA |
cyp21a2-204
(1)
|
Ensembl | 2,991 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-207C13 | ||
| Contained in | BAC | CH211-257P13 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-443N13 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021466882 (1) | |||
| Genomic | GenBank:BX324145 | 196595 nt | ||
| Polypeptide | UniProtKB:A0A8M9NZM6 (1) | 522 aa |
- Yan, Y.L., Titus, T., Desvignes, T., BreMiller, R., Batzel, P., Sydes, J., Farnsworth, D., Dillon, D., Wegner, J., Phillips, J.B., Peirce, J., Dowd, J., Undiagnosed Diseases Network, Buck, C.L., Miller, A., Westerfield, M., Postlethwait, J.H. (2021) A fish with no sex: gonadal and adrenal functions partition between zebrafish NR5A1 co-orthologs. Genetics. 217(2)
- Chen, H., Chen, K., Qiu, X., Xu, H., Mao, G., Zhao, T., Feng, W., Okeke, E.S., Wu, X., Yang, L. (2020) The reproductive toxicity and potential mechanisms of combined exposure to dibutyl phthalate and diisobutyl phthalate in male zebrafish (Danio rerio). Chemosphere. 258:127238
- Kim, C., Choe, H., Park, J., Kim, G., Kim, K., Jeon, H.J., Moon, J.K., Kim, M.J., Lee, S.E. (2020) Molecular mechanisms of developmental toxicities of azoxystrobin and pyraclostrobin toward zebrafish (Danio rerio) embryos: Visualization of abnormal development using two transgenic lines. Environmental pollution (Barking, Essex : 1987). 270:116087
- Kim, Y.C., Lee, S.R., Jeon, H.J., Kim, K., Kim, M.J., Choi, S.D., Lee, S.E. (2020) Acute toxicities of fluorene, fluorene-1-carboxylic acid, and fluorene-9-carboxylic acid on zebrafish embryos (Danio rerio): Molecular mechanisms of developmental toxicities of fluorene-1-carboxylic acid. Chemosphere. 260:127622
- Wang, L., Lin, W., Zha, Q., Guo, H., Zhang, D., Yang, L., Li, L., Li, D., Tang, R. (2020) Persistent Exposure to Environmental Levels of Microcystin-LR Disturbs Cortisol Production via Hypothalamic-Pituitary-Interrenal (HPI) Axis and Subsequently Liver Glucose Metabolism in Adult Male Zebrafish (Danio rerio). toxins. 12(5):
- Shi, C., Lu, Y., Zhai, G., Huang, J., Shang, G., Lou, Q., Li, D., Jin, X., He, J., Du, Z., Gui, J., Yin, Z. (2019) Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity. Journal of molecular cell biology. 12(4):291-304
- Vera-Chang, M.N., Moon, T.W., Trudeau, V.L. (2019) Cortisol disruption and transgenerational alterations in the expression of stress-related genes in zebrafish larvae following fluoxetine exposure. Toxicology and applied pharmacology. 382:114742
- Zhu, B., He, W., Yang, F., Chen, L. (2019) High-throughput transcriptome sequencing reveals the developmental toxicity mechanisms of niclosamide in zebrafish embryo. Chemosphere. 244:125468
- Chen, L., Wang, Y., Giesy, J.P., Chen, F., Shi, T., Chen, J., Xie, P. (2018) Microcystin-LR affects the hypothalamic-pituitary-inter-renal (HPI) axis in early life stages (embryos and larvae) of zebrafish. Environmental pollution (Barking, Essex : 1987). 241:540-548
- Weger, M., Diotel, N., Weger, B.D., Beil, T., Zaucker, A., Eachus, H.L., Oakes, J.A., do Rego, J.L., Storbeck, K.H., Gut, P., Straehle, U., Rastegar, S., Mueller, F., Krone, N. (2018) Expression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co-factors in zebrafish. Journal of neuroendocrinology. 30(4):e12586
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