Gene

pomca

ID
ZDB-GENE-030513-2
Name
proopiomelanocortin a
Symbol
pomca Nomenclature History
Previous Names
  • pomc
  • ACTH
  • beta-endorphin
  • MSH
  • si:bz36d5.2
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Exhibits neuropeptide hormone activity. Involved in several processes, including melanosome localization; neuropeptide signaling pathway; and regulation of hematopoietic stem cell differentiation. Predicted to localize to extracellular region. Is expressed in several structures, including adenohypophyseal placode; adrenal medulla cell; diencephalon; endocrine cell; and male organism. Human ortholog(s) of this gene implicated in familial Mediterranean fever; obesity; and osteoarthritis. Orthologous to human POMC (proopiomelanocortin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
92 figures from 55 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Wagle et al., 2011
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pomca Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
obesity Alliance {Obesity, early-onset, susceptibility to} 601665
Obesity, adrenal insufficiency, and red hair due to POMC deficiency 609734
Associated With pomca Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013531 Pro-opiomelanocortin/corticotropin, ACTH, central region
Domain IPR013532 Opiodes neuropeptide
Domain IPR013593 Pro-opiomelanocortin N-terminal
Family IPR001941 Pro-opiomelanocortin
Domain Details Per Protein
Protein Length Opiodes neuropeptide Pro-opiomelanocortin Pro-opiomelanocortin/corticotropin, ACTH, central region Pro-opiomelanocortin N-terminal
UniProtKB:Q7ZT18 222
UniProtKB:Q8AVA2 222
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-aMSH polyclonal Rabbit
  • IHC
Phoenix Pharmaceuticals, Inc.
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations