FIGURE

Fig. 4

ID

ZDB-FIG-220319-23

Publication

Wen et al., 2022 - Loss of Ripk3 attenuated neutrophil accumulation in a lipopolysaccharide-induced zebrafish inflammatory model

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Fig. 4

The ripk3 deficiency induced limited changes in non-infectious inflammation.

A Experimental design. The caudal fin folds of 3 dpf larvae were injured by sterile syringe needles, and the local accumulation of neutrophils and cytokines expression were detected at 5 hpi. B, C Normal neutrophils attraction towards the injury site. At 0 hpi, few neutrophils could be found in the injury area (red circle). At 5 hpi, similar numbers of neutrophils (red arrows pointed) were attracted to the caudal fin folds (n ≥ 12, Student’s t-test). D The expression levels of pro-inflammatory cytokines (il1b, il6, and cxcl8a) (n ≥ 10, One-way ANOVA). E The expression levels of anti-inflammatory cytokines (il4, il10, and il13) (n ≥ 10, one-way ANOVA).

Expression Data

Genes:	cxcl8a il1b il4 il6 il10 il13
Fish:	AB ripk3^szy12/szy12
Condition:	transection: caudal fin
Anatomical Term:	whole organism
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB ripk3^szy12/szy12
Condition:	transection: caudal fin
Observed In:	neutrophil whole organism
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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