FIGURE

Figure 6

ID

ZDB-FIG-211216-47

Publication

Gomes et al., 2021 - New Findings on LMO7 Transcripts, Proteins and Regulatory Regions in Human and Vertebrate Model Organisms and the Intracellular Distribution in Skeletal Muscle Cells

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Figure 6

hLMO7 transcript variants show conserved intrinsic disorder but differ in the LIM domain. Alignment of hLMO7 isoforms 1 to 5 (UniProt IDs Q8WWI1-1; Q8WWI1-2; Q8WWI1-3; Q8WWI1-4; Q8WWI1-5, respectively) obtained by Clustal Omega [41]. The predicted domains, motifs and intrinsically disordered regions (IDR) reported in the Database of Disordered Protein Predictions (D2P2) [31] are marked by rectangles and the sequences indicated above. Isoform 5 lacks the putative transmembrane α-helix (TM, predicted by Phobius at https://phobius.sbc.su.se/) and the calponin homology domain (CH). Isoform 3 lacks residues 356–690. The LIM domain is missing in isoform 4. Isoforms 2 and 5 do not have the key zinc ion coordination motifs (dark blue rectangles). Cysteine and histidine residues that might also be involved in Zn(II) binding are marked in purple and blue, respectively. NLS, nuclear localization signal predicted by NLSdb (https://rostlab.org/services/nlsdb/).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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