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Fig. 1

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ZDB-FIG-211006-1

Publication

Leach et al., 2021 - The immune response is a critical regulator of zebrafish retinal pigment epithelium regeneration

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Fig. 1

Enrichment of immune system genes during RPE regeneration. (A) Experimental workflow showing steps for tissue processing (i, ii) and isolation of eGFP⁺ RPE (iii, iv). Example 9 dpf and 4 dpi FACS plots showing cell sorting gate (iii; green). (B and C) Top Reactome pathways enriched from groups of significant DEGs at 2 dpi/7 dpf (B) and 4 dpi/9 dpf (C). Numbers in parentheses indicate quantities of significantly enriched DEGs. (D) Heatmap showing hierarchical clustering of immune-related genes in the top 50 up-regulated DEG sets from 2 dpi/7 dpf and 4 dpi/9 dpf (SI Appendix, Tables S1 and S2). Heatmap legend represents log₂ (transcripts per million +1).

Expression Data

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Antibody Labeling

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Acknowledgments

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