FIGURE

Figure 6

ID

ZDB-FIG-210902-146

Publication

Sarkar et al., 2021 - Involvement of Oxidative and Endoplasmic Reticulum Stress in RDH12-Related Retinopathies

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Figure 6

Analysis of oxidative stress in adult rdh12^u533 zebrafish retina. (A) atRAL levels in 16 mpf retina were analysed by HPLC. Activity of antioxidant enzymes SOD (B) and CAT (C) was analysed in 16 mpf retina, but no significant differences were found between wt and rdh12^u533 mutant fish. (D–I) Expression of oxidative stress markers was analysed by RT-qPCR in retinas from wt and rdh12^u533 fish at 12 mpf. mRNA expression of sod2 was significantly reduced in rdh12^u533 fish retinas. Data are expressed as mean ± SEM; * p < 0.05.

Expression Data

Genes:	cat gpx1a hmox1a nfe2l2a sod1 sod2
Fish:	AB rdh12^{zf3693/zf3693}
Anatomical Term:	retina
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rdh12^{zf3693/zf3693}
Observed In:	retina retina all-trans-retinal retina catalase activity retina superoxide dismutase activity
Stage:	Adult

Phenotype Detail

Acknowledgments

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