Gene

hmox1a

ID

ZDB-GENE-030131-3102

Name

heme oxygenase 1a

Symbol

hmox1a Nomenclature History

Previous Names

hmox1
fc27c04
wu:fc27c04
zgc:65984 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Exhibits heme oxygenase (decyclizing) activity. Involved in cellular response to xenobiotic stimulus; regulation of respiratory gaseous exchange; and response to hypoxia. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); factor VIII deficiency; lung disease (multiple); and sickle cell anemia. Is expressed in several structures, including heart; hematopoietic system; lens; neuroepithelial cell; and solid lens vesicle. Orthologous to human HMOX1 (heme oxygenase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

59 figures from 36 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6909276 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hmox1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
chronic obstructive pulmonary disease	Alliance	{Pulmonary disease, chronic obstructive, susceptibility to}	606963
		Heme oxygenase-1 deficiency	614034

Associated With hmox1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018207	Haem oxygenase conserved site
Family	IPR002051	Haem oxygenase
Family	IPR016053	Haem oxygenase-like
Homologous_superfamily	IPR016084	Haem oxygenase-like, multi-helical