Gene

sod1

ID
ZDB-GENE-990415-258
Name
superoxide dismutase 1, soluble
Symbol
sod1 Nomenclature History
Previous Names
  • ZSOD (1)
  • Cu/Zn-SOD (1)
  • cuzn
  • sod(Cu/Zn) (1)
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Exhibits superoxide dismutase activity. Involved in several processes, including neuron cellular homeostasis; response to metal ion; and response to methylmercury. Predicted to localize to several cellular components, including extracellular space; mitochondrion; and peroxisome. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Is expressed in several structures, including blastoderm; blastodisc; liver; musculature system; and nervous system. Orthologous to human SOD1 (superoxide dismutase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
36 figures from 27 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sod1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
amyotrophic lateral sclerosis type 1 Alliance Amyotrophic lateral sclerosis 1 105400
Spastic tetraplegia and axial hypotonia, progressive 618598
Associated With sod1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018152 Superoxide dismutase, copper/zinc, binding site
Domain IPR001424 Superoxide dismutase, copper/zinc binding domain
Family IPR024134 Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone
Homologous_superfamily IPR036423 Superoxide dismutase-like, copper/zinc binding domain superfamily
Domain Details Per Protein
Protein Length Superoxide dismutase, copper/zinc binding domain Superoxide dismutase, copper/zinc, binding site Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone Superoxide dismutase-like, copper/zinc binding domain superfamily
UniProtKB:O73872 154
UniProtKB:B2GRH9 154
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-sod1 polyclonal IgG Rabbit
  • WB
Santa Cruz Biotechnology, Inc.
5
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations