Gene
cat
- ID
- ZDB-GENE-000210-20
- Name
- catalase
- Symbol
- cat Nomenclature History
- Previous Names
-
- fb68a12
- wu:fb68a12 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable catalase activity and heme binding activity. Acts upstream of or within response to copper ion. Predicted to be located in peroxisomal matrix. Predicted to be active in mitochondrion and peroxisome. Is expressed in several structures, including digestive system; eye; female organism; gill; and ventricular zone. Human ortholog(s) of this gene implicated in several diseases, including acatalasia; eye disease (multiple); lung disease (multiple); osteonecrosis; and pseudoxanthoma elasticum. Orthologous to human CAT (catalase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 45 figures from 33 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56675 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Albadri et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ic3036 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
| sa13124 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa16024 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31106 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38000 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cat | Albadri et al., 2019 | |
| CRISPR2-cat | Albadri et al., 2019 | |
| MO1-cat | N/A | Kishi et al., 2008 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acatalasia | Alliance | Acatalasemia | 614097 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Catalase active site | Catalase, clade 3 | Catalase core domain | Catalase haem-binding site | Catalase immune-responsive domain | Catalase, mono-functional, haem-containing | Catalase, mono-functional, haem-containing, clades 1 and 3 | Catalase superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9PT92
|
526 | ||||||||
|
UniProtKB:A0A8M1PAV5
|
526 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-cat | polyclonal | Rabbit |
|
Sigma-Aldrich
|
3 | ||
| Ab4-cat | polyclonal | IgG | Rabbit |
|
Athens Research and Technology
|
1 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(ins:cat,ins:Hsa.HIST1H2BJ-mCherry,cryaa:YFP) |
| 1 | Ahmed Alfar et al., 2017 | ||
| Tg(krt1-19e:cat,myl7:mCherry) |
|
| 1 | Zebrafish Nomenclature Committee | |
| Tg(myl7:cat-DsRed) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-463L14 | ZFIN Curated Data | |
| Encodes | EST | fb68a12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56675 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130912 (1) | 2303 nt | ||
| Genomic | GenBank:CU694456 (2) | 25610 nt | ||
| Polypeptide | UniProtKB:A0A8M1PAV5 (1) | 526 aa |
- Raas, Q., Wood, A., Stevenson, T.J., Swartwood, S., Liu, S., Kannan, R.M., Kannan, S., Bonkowsky, J.L. (2024) Generation and characterization of a zebrafish gain-of-function ACOX1 Mitchell disease model. Frontiers in pediatrics. 12:13268861326886
- Subba, R., Fasciolo, G., Geremia, E., Muscari Tomajoli, M.T., Petito, A., Carrella, S., Mondal, A.C., Napolitano, G., Venditti, P. (2024) Simultaneous induction of systemic hyperglycaemia and stress impairs brain redox homeostasis in the adult zebrafish. Archives of biochemistry and biophysics. 759:110101
- Xu, Y., Zhang, S., Bao, Y., Luan, J., Fu, Z., Sun, M., Zhao, X., Feng, X. (2024) Melatonin protects zebrafish pancreatic development and physiological rhythms from sodium propionate-induced disturbances via the hypothalamic-pituitary-thyroid axis. Journal of the science of food and agriculture. 104(12):7454-7463
- Zhong, X., Zhang, G., Huang, J., Chen, L., Shi, Y., Wang, D., Zheng, Q., Su, H., Li, X., Wang, C., Zhang, J., Guo, L. (2024) Effects of Intestinal Microbiota on the Biological Transformation of Arsenic in Zebrafish: Contribution and Mechanism. Environmental science & technology. 58(5):2247-2259
- Zhou, R., Ding, R.C., Yu, Q., Qiu, C.Z., Zhang, H.Y., Yin, Z.J., Ren, D.L. (2024) Metformin Attenuates Neutrophil Recruitment through the H3K18 Lactylation/Reactive Oxygen Species Pathway in Zebrafish. Antioxidants (Basel, Switzerland). 13(2):
- Carletti, A., Rosa, J.T., Pes, K., Borges, I., Santos, T., Barreira, L., Varela, J., Pereira, H., Cancela, M.L., Gavaia, P.J., Laizé, V. (2023) The osteogenic and mineralogenic potential of the microalgae Skeletonema costatum and Tetraselmis striata CTP4 in fish models. Cellular and molecular life sciences : CMLS. 80:310310
- Gómez Sánchez, A., Colucci, P., Moran, A., Moya López, A., Colligris, B., Álvarez, Y., Kennedy, B.N. (2023) Systemic treatment with cigarette smoke extract affects zebrafish visual behaviour, intraocular vasculature morphology and outer segment phagocytosis. Open research Europe. 3:4848
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Medkova, D., Hollerova, A., Blahova, J., Marsalek, P., Mares, J., Hodkovicova, N., Doubkova, V., Hesova, R., Tichy, F., Faldyna, M., Taştan, Y., Kotoucek, J., Svobodova, Z., Lakdawala, P. (2023) Medicine designed to combat diseases of affluence affects the early development of fish. How do plastic microparticles contribute?. The Science of the total environment. 904:166378
- Nayak, S.P.R.R., Boopathi, S., Priya, P.S., Pasupuleti, M., Pachaiappan, R., Almutairi, B.O., Arokiyaraj, S., Arockiaraj, J. (2023) Luteolin, a promising quorum quencher mitigates virulence factors production in Pseudomonas aeruginosa - In vitro and in vivo approach. Microbial pathogenesis. 180:106123
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