Gene

cat

ID
ZDB-GENE-000210-20
Name
catalase
Symbol
cat Nomenclature History
Previous Names
  • fb68a12
  • wu:fb68a12 (1)
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to enable catalase activity and heme binding activity. Acts upstream of or within response to copper ion. Predicted to be located in peroxisomal matrix. Predicted to be active in mitochondrion and peroxisome. Is expressed in several structures, including digestive system; eye; female organism; gill; and ventricular zone. Human ortholog(s) of this gene implicated in several diseases, including acatalasia; eye disease (multiple); lung disease (multiple); osteonecrosis; and pseudoxanthoma elasticum. Orthologous to human CAT (catalase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
45 figures from 33 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Albadri et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ic3036Allele with one deletionUnknownFrameshift, Premature StopCRISPR
sa13124Allele with one point mutationUnknownSplice SiteENU
sa16024Allele with one point mutationUnknownPremature StopENU
sa31106Allele with one point mutationUnknownPremature StopENU
sa38000Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
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Human Disease
Associated With cat Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acatalasia Alliance Acatalasemia 614097
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Associated With cat Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR024708 Catalase active site
Binding_site IPR002226 Catalase haem-binding site
Domain IPR010582 Catalase immune-responsive domain
Domain IPR011614 Catalase core domain
Family IPR018028 Catalase, mono-functional, haem-containing
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Domain Details Per Protein
Protein Length Catalase active site Catalase, clade 3 Catalase core domain Catalase haem-binding site Catalase immune-responsive domain Catalase, mono-functional, haem-containing Catalase, mono-functional, haem-containing, clades 1 and 3 Catalase superfamily
UniProtKB:Q9PT92 526
UniProtKB:A0A8M1PAV5 526
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 25
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA cat-201 (1) Ensembl 2,054 nt
mRNA cat-202 (1) Ensembl 4,525 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-cat polyclonal Rabbit
Sigma-Aldrich
3
Ab4-cat polyclonal IgG Rabbit
  • IHC
Athens Research and Technology
1
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Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(ins:cat,ins:Hsa.HIST1H2BJ-mCherry,cryaa:YFP)
  • Danio rerio
  • Homo sapiens
1Ahmed Alfar et al., 2017
Tg(krt1-19e:cat,myl7:mCherry)
  • Danio rerio
1Zebrafish Nomenclature Committee
Tg(myl7:cat-DsRed)
  • Danio rerio
1 (2)
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inFosmidCH1073-463L14ZFIN Curated Data
EncodesESTfb68a12ZFIN Curated Data
EncodescDNAMGC:56675ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanCAT11
Amino acid sequence comparison (2)
Other (1)
MouseCat2
Amino acid sequence comparison (2)
Citations
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