Gene

cat

ID

ZDB-GENE-000210-20

Name

catalase

Symbol

cat Nomenclature History

Previous Names

fb68a12
wu:fb68a12 (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable catalase activity and heme binding activity. Acts upstream of or within response to copper ion. Predicted to be located in peroxisomal matrix. Predicted to be active in mitochondrion and peroxisome. Is expressed in several structures, including digestive system; eye; female organism; gill; and ventricular zone. Human ortholog(s) of this gene implicated in several diseases, including acatalasia; eye disease (multiple); lung disease (multiple); osteonecrosis; and pseudoxanthoma elasticum. Orthologous to human CAT (catalase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

45 figures from 33 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56675 (5 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Albadri et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cat Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acatalasia	Alliance	Acatalasemia	614097

Associated With cat Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR024708	Catalase active site
Binding_site	IPR002226	Catalase haem-binding site
Domain	IPR010582	Catalase immune-responsive domain
Domain	IPR011614	Catalase core domain
Family	IPR018028	Catalase, mono-functional, haem-containing
Family	IPR024711	Catalase, mono-functional, haem-containing, clades 1 and 3
Family	IPR040333	Catalase, clade 3
Homologous_superfamily	IPR020835	Catalase superfamily