FIGURE
Figure 3
- ID
- ZDB-FIG-210902-143
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- Sarkar et al., 2021 - Involvement of Oxidative and Endoplasmic Reticulum Stress in RDH12-Related Retinopathies
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Figure 3
atRAL-induced ER stress was attenuated by pregabalin. Cells were dosed with 50 µM atRAL, 1 mM pregabalin (PGB), or both for 24 h. RT-qPCR was performed analysing the expres-sion of ER stress markers. Dosing with atRAL significantly increased expression of sXBP1 (A′, B′, C′), ATF4 (A″, B″, C″), and CHOP (A‴, B‴, C‴) in p.Y226C (A), p.A109P (B), and p.S13 (C) cell lines. Dosing with pregabalin reduced expression of ER stress markers. Statistical significance was analysed using one-way ANOVA and Sidak’s multiple comparison test. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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