Gene

nfe2l2a

ID
ZDB-GENE-030723-2
Name
nuclear factor, erythroid 2-like 2a
Symbol
nfe2l2a Nomenclature History
Previous Names
  • nfe2l2
  • Nrf2 (1)
  • Nrf2a (1)
  • wu:fc15g09 (1)
  • wu:fj67e03 (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Exhibits protein heterodimerization activity and transcription regulatory region sequence-specific DNA binding activity. Contributes to DNA-binding transcription factor activity. Involved in several processes, including cellular response to oxidative stress; cellular response to prostaglandin stimulus; and positive regulation of transcription, DNA-templated. Localizes to cytoplasm; nucleus; and transcription regulator complex. Is expressed in several structures, including digestive system; gill; heart; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; and macular degeneration. Orthologous to human NFE2L2 (nuclear factor, erythroid 2 like 2).
Genome Resources
Note
None
Expression
All Expression Data
14 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nfe2l2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Immunodeficiency, developmental delay, and hypohomocysteinemia 617744
Associated With nfe2l2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004826 Basic leucine zipper domain, Maf-type
Domain IPR004827 Basic-leucine zipper domain
Family IPR029845 Nuclear factor erythroid 2-related factor 2
Homologous_superfamily IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Basic-leucine zipper domain Basic leucine zipper domain, Maf-type Nuclear factor erythroid 2-related factor 2 Transcription factor, Skn-1-like, DNA-binding domain superfamily
UniProtKB:Q7ZVI2 586
UniProtKB:Q8JIM1 586
UniProtKB:A7YYH1 586
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations