Gene
nfe2l2a
- ID
- ZDB-GENE-030723-2
- Name
- nfe2 like bZIP transcription factor 2a
- Symbol
- nfe2l2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables protein heterodimerization activity and transcription cis-regulatory region binding activity. Contributes to DNA-binding transcription factor activity. Acts upstream of or within several processes, including cellular response to prostaglandin stimulus; larval feeding behavior; and positive regulation of DNA-templated transcription. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including digestive system; female organism; heart; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; macular degeneration; and tuberculosis. Orthologous to human NFE2L2 (NFE2 like bZIP transcription factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 39 figures from 36 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| dw213 | Allele with one deletion | Unknown | Inframe Deletion | CRISPR | |
| dw214a | Allele with one deletion | Unknown | Inframe Deletion | CRISPR | |
| fh318 | Allele with one point mutation | Unknown | Missense | ENU | |
| fh319 | Allele with one point mutation | Unknown | Unknown | ENU | |
| ihb247 | Allele with one delins | Exon 2 | Unknown | CRISPR | |
| ihb256 | Allele with one deletion | Exon 4 | Unknown | CRISPR | |
| it321 | Allele with one delins | Exon 2 | Unknown | CRISPR | |
| la026758Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026760Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| nfe2l2a_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Immunodeficiency, developmental delay, and hypohomocysteinemia | 617744 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004826 | Basic leucine zipper domain, Maf-type |
| Domain | IPR004827 | Basic-leucine zipper domain |
| Family | IPR047167 | Nuclear Factor Erythroid-derived 2-like |
| Homologous_superfamily | IPR008917 | Transcription factor, Skn-1-like, DNA-binding domain superfamily |
| Homologous_superfamily | IPR046347 | Basic-leucine zipper domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Basic-leucine zipper domain | Basic leucine zipper domain, Maf-type | Basic-leucine zipper domain superfamily | Nuclear Factor Erythroid-derived 2-like | Transcription factor, Skn-1-like, DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q8JIM1 | InterPro | 586 | |||||
| UniProtKB:A0A8M2BJQ0 | InterPro | 585 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nfe2l2a-201
(1)
|
Ensembl | 4,739 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-230E14 | ZFIN Curated Data | |
| Encodes | EST | fc15g09 | ||
| Encodes | EST | fj67e03 | ||
| Encodes | cDNA | MGC:56001 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174016 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_182889 (1) | 2194 nt | ||
| Genomic | GenBank:CR848724 (2) | 154185 nt | ||
| Polypeptide | UniProtKB:Q8JIM1 (1) | 586 aa |
- Abate, G., Pezzotta, A., Pucci, M., Bortolotto, V., Ribaudo, G., Bonini, S.A., Mastinu, A., Maccarinelli, G., Ongaro, A., Tirelli, E., Zizioli, D., Gianoncelli, A., Memo, M., Grilli, M., Uberti, D. (2024) The Bioactive Gamma-Oryzanol from Oryza sativa L. Promotes Neuronal Differentiation in Different In Vitro and In Vivo Models. Antioxidants (Basel, Switzerland). 13(8):
- Li, Q., Pei, R., Chen, E., Zheng, F., Zhang, Y., Meng, S. (2024) Efficacy of Jiuzao polysaccharides in ameliorating alcoholic fatty liver disease and modulating gut microbiota. Heliyon. 10:e26167e26167
- Marques, E.S., Severance, E.G., Arsenault, P., Zahn, S.M., Timme-Laragy, A.R. (2024) Activation of Nrf2 at Critical Windows of Development Alters Tissue-Specific Protein S-Glutathionylation in the Zebrafish (Danio rerio) Embryo. Antioxidants (Basel, Switzerland). 13(8):
- Ranasinghe, T., Seo, Y., Park, H.C., Choe, S.K., Cha, S.H. (2024) Rotenone exposure causes features of Parkinson`s disease pathology linked with muscle atrophy in developing zebrafish embryo. Journal of hazardous materials. 480:136215136215
- Subba, R., Fasciolo, G., Geremia, E., Muscari Tomajoli, M.T., Petito, A., Carrella, S., Mondal, A.C., Napolitano, G., Venditti, P. (2024) Simultaneous induction of systemic hyperglycaemia and stress impairs brain redox homeostasis in the adult zebrafish. Archives of biochemistry and biophysics. 759:110101
- Tan, V.W.T., Salmi, T.M., Karamalakis, A.P., Gillespie, A., Ong, A.J.S., Balic, J.J., Chan, Y.C., Bladen, C.E., Brown, K.K., Dawson, M.A., Cox, A.G. (2024) SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway. Developmental Cell. 59(7):898-910.e6
- Zang, X., Wang, Y., Han, C., Cui, L., Liu, H., Tian, S., Liu, K., Li, P., Sun, C., Xia, Q., Zhang, Y. (2024) 2-Acetamidophenol (2-AAP) Suppresses the Progression of Atherosclerosis by Alleviating Hyperlipidemia and Attenuating the Ferroptosis Pathway. Marine drugs. 22(11):
- Bian, L., Nguyen, V.T., Tamaoki, J., Endo, Y., Dong, G., Sato, A., Kobayashi, M. (2023) Genetic hyperactivation of Nrf2 causes larval lethality in Keap1a and Keap1b-double-knockout zebrafish. Redox Biology. 62:102673102673
- Chang, S.H., Giong, H.K., Kim, D.Y., Kim, S., Oh, S., Yun, U.J., Lee, J.S., Park, K.W. (2023) Activation of Nrf2 by sulfuretin stimulates chondrocyte differentiation and increases bone lengths in zebrafish. BMB reports. 56:496501496-501
- Chen, A.Q., Xue, M., Qiu, C.Z., Zhang, H.Y., Zhou, R., Zhang, L., Yin, Z.J., Ren, D.L. (2023) Circadian clock1a coordinates neutrophil recruitment via nfe212a/duox-reactive oxygen species pathway in zebrafish. Cell Reports. 42:113179113179
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