Gene

nfe2l2a

ID

ZDB-GENE-030723-2

Name

nfe2 like bZIP transcription factor 2a

Symbol

nfe2l2a Nomenclature History

Previous Names

nfe2l2
Nrf2 (1)
Nrf2a (1)
wu:fc15g09 (1)
wu:fj67e03 (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Exhibits protein heterodimerization activity and transcription regulatory region sequence-specific DNA binding activity. Contributes to DNA-binding transcription factor activity. Involved in several processes, including cellular response to oxidative stress; cellular response to prostaglandin stimulus; and positive regulation of transcription, DNA-templated. Localizes to cytoplasm; nucleus; and transcription regulator complex. Is expressed in several structures, including digestive system; gill; heart; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; and macular degeneration. Orthologous to human NFE2L2 (nuclear factor, erythroid 2 like 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

26 figures from 25 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nfe2l2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Immunodeficiency, developmental delay, and hypohomocysteinemia	617744

Associated With nfe2l2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004826	Basic leucine zipper domain, Maf-type
Domain	IPR004827	Basic-leucine zipper domain
Family	IPR029845	Nuclear factor erythroid 2-related factor 2
Homologous_superfamily	IPR008917	Transcription factor, Skn-1-like, DNA-binding domain superfamily