Gene
gpx1a
- ID
- ZDB-GENE-030410-1
- Name
- glutathione peroxidase 1a
- Symbol
- gpx1a Nomenclature History
- Previous Names
-
- gpx1
- cb690 (1)
- zgc:103683
- zgc:92737
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable glutathione peroxidase activity. Predicted to be involved in several processes, including hydrogen peroxide catabolic process; response to hydrogen peroxide; and response to selenium ion. Predicted to act upstream of or within response to oxidative stress. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including Kupffer's vesicle; digestive system; female organism; optic tectum; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cardiovascular system disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and respiratory system cancer (multiple). Orthologous to human GPX1 (glutathione peroxidase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 42 figures from 33 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb690 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Hemolytic anemia due to glutathione peroxidase deficiency | 614164 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Glutathione peroxidase | Glutathione peroxidase active site | Thioredoxin-like superfamily |
|---|---|---|---|---|
|
UniProtKB:Q5XJ48
|
142 | |||
|
UniProtKB:A0A8M1N370
|
191 |
Interactions and Pathways
No data available
Plasmids
No data available