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Gene

gpx1a

ID
ZDB-GENE-030410-1
Name
glutathione peroxidase 1a
Symbol
gpx1a Nomenclature History
Previous Names
  • gpx1
  • cb690 (1)
  • zgc:103683
  • zgc:92737
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to enable glutathione peroxidase activity. Predicted to be involved in several processes, including glutathione metabolic process; hydrogen peroxide catabolic process; and response to selenium ion. Predicted to act upstream of or within response to oxidative stress. Predicted to be active in cytosol and mitochondrion. Is expressed in Kupffer's vesicle; digestive system; muscle; optic tectum; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cardiovascular system disease (multiple); hematologic cancer (multiple); nutritional deficiency disease (multiple); and pseudoxanthoma elasticum. Orthologous to human GPX1 (glutathione peroxidase 1) and GPX2 (glutathione peroxidase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
28 figures from 20 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gpx1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Hemolytic anemia due to glutathione peroxidase deficiency 614164
Associated With gpx1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR029759 Glutathione peroxidase active site
Family IPR000889 Glutathione peroxidase
Homologous_superfamily IPR036249 Thioredoxin-like superfamily
Domain Details Per Protein
Protein Length Glutathione peroxidase Glutathione peroxidase active site Thioredoxin-like superfamily
UniProtKB:Q5XJ48 142
UniProtKB:B0V1T0 136
UniProtKB:Q802G3 181
UniProtKB:F6NYT7 191
UniProtKB:A0A2R8QC13 184
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations