FIGURE

Fig. 2

ID

ZDB-FIG-210726-65

Publication

Lopez-Ramirez et al., 2021 - Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells

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Fig. 2

HKi1 is an inhibitor of the HEG1–KRIT1 interaction. (A) Chemical structure of HKi1. LE = (1.37/HA) x pIC₅₀ where HA is the number of non H atoms present in the ligand; LLE = pIC₅₀-LogP. (B) Competition binding curve of 70 nM EGFP-KRIT1 FERM domain binding to 150 nM HEG1 on the beads with increasing amounts of HKi1. HKi1 had poor solubility in our buffer and concentrations >30 μM could not be reached.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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