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Figure Caption
Fig. 2 HKi1 is an inhibitor of the HEG1–KRIT1 interaction. (A) Chemical structure of HKi1. LE = (1.37/HA) x pIC50 where HA is the number of non H atoms present in the ligand; LLE = pIC50-LogP. (B) Competition binding curve of 70 nM EGFP-KRIT1 FERM domain binding to 150 nM HEG1 on the beads with increasing amounts of HKi1. HKi1 had poor solubility in our buffer and concentrations >30 μM could not be reached.
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