FIGURE

Figure 1

ID

ZDB-FIG-210717-5

Publication

Xie et al., 2021 - Congenital Asplenia Interrupts Immune Homeostasis and Leads to Excessive Systemic Inflammation in Zebrafish

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Figure 1

Effects of congenital asplenia on inflammatory response in zebrafish larvae. (A) The expression of inflammatory response–related genes after pathogenic A. hydrophila infection in zebrafish larvae. (B) The expression of inflammatory response–related genes after LPS exposure. (C, D) The expression of Il1β, Il6, and Tnfα proteins after A. hydrophila challenge and LPS by ELISA. (E) A high aggregation of apoptotic cells was observed in the trunk of congenitally asplenic zebrafish by TUNEL assay. The white arrowhead indicates TUNEL-positive cells. Different letters (a, b, c, etc.) indicate significant differences (p < .05).

Expression Data

Genes:	il1b il6 il10 nfkb2 tnfa tnfb
Fish:	tlx1^cq201/cq201
Conditions:	chemical treatment by environment: lipopolysaccharide bacterial treatment by exposure to environment: Aeromonas hydrophila
Anatomical Term:	whole organism
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tlx1^cq201/cq201
Conditions:	chemical treatment by environment: lipopolysaccharide bacterial treatment by exposure to environment: Aeromonas hydrophila
Observed In:	trunk apoptotic process whole organism
Stage Range:	Day 4 to Day 6

Phenotype Detail

Acknowledgments

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