FIGURE

Fig 7

ID

ZDB-FIG-210623-62

Publication

Swartz et al., 2021 - Variation in phenotypes from a Bmp-Gata3 genetic pathway is modulated by Shh signaling

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Fig 7

Gata3 functions downstream of Bmp in palate development.

(A-C) Flat mounts of 4 dpf neurocrania anterior to the left. (A) Wild type phenotype of the hsp:DN-BmpR1a with no heat shock. (B) Severely affected trabeculae typical of the hsp:DN-BmpR1a when heat shocked at 24 hpf. (C) A typical rescue of the hsp:DN-BmpR1a;hsp:GATA3-EGFP heat shock phenotype at 24 hpf. (D) Graph depicting quantification of heat shock phenotype scores at three different heat shock time points. Trabeculae phenotype is rescued significantly by hsp:GATA3-EGFP at 24 and 26 hpf. Phenotypes are also rescued at 28 hpf, but to a lesser degree as the overall phenotype is not as severe. A two way ANOVA was performed with Holm-Sidak’s multiple comparisons test. At all heat shock timepoints the hsp:DN-BmpR1a controls had significantly worse phenotype when compared to the hsp:DN-BmpR1a;hsp:GATA3-EGFP double heat shock.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	w30Tg/w30Tg au34Tg/au34Tg; w30Tg/w30Tg
Condition:	heat shock
Observed In:	neurocranial trabecula
Stage:	Day 4

Phenotype Detail

Acknowledgments

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