FIGURE

Figure 5

ID

ZDB-FIG-210409-34

Publication

Han et al., 2021 - Zebrafish mafbb Mutants Display Osteoclast Over-Activation and Bone Deformity Resembling Osteolysis in MCTO Patients

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Figure 5

Expansion of definitive myeloid lineages in mafbb mutants. (A) WISH of runx1, cmyb, mpx, rag1 and hbbe1, and benzidine staining of embryos during the early development stages. (B) Quantification of WISH and benzidine staining results in embryos (n = 50–100 embryos per group). (C) Images of the kidney in adult zebrafish. May-Grunwald and Giemsa (MGG) staining of the whole kidney marrow (WKM) blood smears from zebrafish at 9-month-old. Myelomonocytes (blue arrows); lymphocytes (red arrows); precursors (black arrows). (D) Summary of various hematopoietic cells from adult WKM. 3 zebrafishes and about 2000 cells in total were analyzed for each group. WT, wild type; HOM, mafbb^d11/d11. Results in B and D are expressed as mean ± SEM, (* p < 0.05, ** p < 0.01, t test, ns, not significant).

Expression Data

Genes:	hbbe1.1 mpx myb rag1 runx1
Fish:	AB mafbb^{zf3556/zf3556} (AB)
Anatomical Terms:	hematopoietic multipotent progenitor cell neutrophil neutrophil progenitor cell nucleate erythrocyte T cell
Stage Range:	Prim-5 to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mafbb^{zf3556/zf3556} (AB)
Observed In:	head nucleate erythrocyte head kidney hematopoietic multipotent progenitor cell head kidney lymphocyte head kidney monocyte head kidney myeloid cell post-vent region hematopoietic multipotent progenitor cell post-vent region neutrophil post-vent region neutrophil progenitor cell post-vent region nucleate erythrocyte T cell
Stage Range:	Prim-5 to Adult

Phenotype Detail

Acknowledgments

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