FIGURE

Figure 4

ID

ZDB-FIG-210310-108

Publication

Zizioli et al., 2021 - Development of BCR-ABL1 Transgenic Zebrafish Model Reproducing Chronic Myeloid Leukemia (CML) Like-Disease and Providing a New Insight into CML Mechanisms

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Figure 4

BCR-ABL1 induces a granulopoiesis expansion and granulocytes differentiation. Whole mount in situ hybridization (WISH) of scl at 24 hpf in Wild Type (WT) (A) and in Tg BCR-ABL1 (B). WISH at 28 hpf for pu1 (C,D); mpx1 (E,F); and L-plastin (G,H) respectively in WT and tg BCR-ABL1 fishes. The experiments were performed in duplicate; numbers in each panel represent total embryos used for the experiment and embryos with the result shown in the image. In each panel, red ovals indicate the positive signals of mpx1 and L-plastin in posterior blood island. Red arrows respectively indicate the mpx1 (F) and L-plastin (H) positive cells in the anterior part of the embryos. Statistical analysis of mpx1+ (I) and L-plastin+ (L) signals counted in posterior blood islands. Unpaired, two-tailed t-test **** p < 0.0001.

Expression Data

Genes:	lcp1 mpx spi1b tal1
Fish:	zf3525Tg; zf3526Tg (AB)
Condition:	heat shock
Anatomical Term:	blood island
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	zf3525Tg; zf3526Tg (AB)
Condition:	heat shock
Observed In:	blood island myeloid cell
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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