FIGURE

Figure 5

ID

ZDB-FIG-210310-109

Publication

Zizioli et al., 2021 - Development of BCR-ABL1 Transgenic Zebrafish Model Reproducing Chronic Myeloid Leukemia (CML) Like-Disease and Providing a New Insight into CML Mechanisms

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Figure 5

Transcriptional changes of erythropoiesis markers. Whole mount in situ hybridization (WISH) at 28 hpf of c-myb (A,B), gata1 (C,D); VE-cadherin (E,F) in wild type (WT) and Tg BCR-ABL1 fish, respectively. The experiments were performed in duplicate; numbers in each panel represent total embryos used for the experiment and embryos with the result shown in the image. Red arrow in (D) indicate the downregulated expression level of gata1 in caudal plexus in Tg BCR-ABL1 fish; (F) single black asterisk indicate the downregulated expression level of VE-cadherin in caudal plexus in Tg BCR-ABL1 fish; double black asterisks indicate the not well-formed nascent vessels in Tg BCR-ABL1 fish.

Expression Data

Genes:	cdh5 gata1a myb
Fish:	zf3525Tg; zf3526Tg (AB)
Condition:	heat shock
Anatomical Terms:	caudal vein plexus erythroid lineage cell
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	zf3525Tg; zf3526Tg (AB)
Condition:	heat shock
Observed In:	caudal vein plexus erythrocyte differentiation erythroid lineage cell vasculature development
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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