FIGURE

Fig 7

ID

ZDB-FIG-200829-86

Publication

Zhang et al., 2020 - THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis

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Fig 7

Inhibition of P53 signaling alleviated the <italic>thoc1</italic>-deficiency induced apoptosis in neuromasts.

(a, b) Statistical analysis of the hair cell clusters in control (n = 8), ctrl + P53 inhibitor treatment (n = 9), thoc1 KO (n = 8), and thoc1 KO + P53 inhibitor treatment embryos (n = 7). One-way ANOVA, ****, p<0.0001; ***, p<0.001; **, p<0.01. (c) TUNEL analysis of the neuromasts in control (n = 7), thoc1 KO (n = 7), and thoc1 KO + P53 inhibitor treatment embryos (n = 7). Green: TUNEL staining. Blue: DAPI staining of the cell nuclei. (d) Statistical analysis of the number of apoptotic cells per neuromast in control, thoc1 KO, and thoc1 KO + P53 inhibitor treatment embryos. One-way ANOVA, ****, p<0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s356tTg + CRISPR1-thoc1
Condition:	chemical treatment: pharmaceutical
Knockdown Reagent:	CRISPR1-thoc1
Observed In:	neuromast hair cell neuromast hair cell apoptotic process
Stage:	Day 4

Phenotype Detail

Acknowledgments

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