FIGURE

Figure 6.

ID

ZDB-FIG-200829-69

Publication

Liu et al., 2020 - TMEM216 Deletion Causes Mislocalization of Cone Opsin and Rhodopsin and Photoreceptor Degeneration in Zebrafish

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Figure 6.

Defective organization of F-actin in tmem216 knockout photoreceptors. Cryosections were immunostained with 4D2 (red). Some sections were stained with Phalloidin-RITC for F-actin (red). (A, C) 4D2 staining of wildtype and tmem216^snyΔ175 homozygous retina. 4D2 labels rod outer segments in the wildtype zebrafish (arrow in A); however, its reactivity was frequently mislocalized to the rod cell body in the knockouts (arrowheads in C). (B, D) Phalloidin staining in wildtype and tmem216^snyΔ175 homozygous retina. Vertically oriented F-actin in the wildtype (arrows in B) were disrupted in tmem216^snyΔ175 homozygous retina (arrowheads in D). Scale bar in H: 6 µm.

Expression Data

Antibody:	Ab5-rho
Fish:	AB/TU tmem216^{zf3394/zf3394} (AB/TU)
Anatomical Terms:	retinal rod cell cell body retinal rod cell rod photoreceptor outer segment
Stage:	Days 14-20

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tmem216^{zf3394/zf3394} (AB/TU)
Observed In:	photoreceptor cell filamentous actin retinal rod cell cell body
Stage:	Days 14-20

Phenotype Detail

Acknowledgments

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