FIGURE

Figure S4

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ZDB-FIG-191230-901
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Baron et al., 2019 - Cell Type Purification by Single-Cell Transcriptome-Trained Sorting
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Figure S4

HSPC Enrichments with Stained WKM Cells on BD FACSInflux, Related to Figures 3 and 4

(A) Contour plots of stained WKM cells showing experimental sorting gates for HSPC for the WKM 11 experiment (representative example for WKM 11, 12 and 13 HSPC enrichment experiments) on BD FACSInflux. Sorted cells passed through gate 1 and gate 2. Percentages of events within each gate are indicated.

(B) t-SNE map of zebrafish WKM TD3 where HSPCs inside and outside of GateID gates are colored in red and blue respectively.

(C) Projection of the sorted GateID HSPCs for WKM 10 in FSC Height versus SSC Height (representative example for WKM 11, 12 and 13 HSPC enrichment experiments).

(D–F) Barplots and t-SNE maps showing the outcome of HSPC enrichments for (D) WKM 11, (E) WKM 12 and (F) WKM 13 on BD FACSInflux.

(G) Scatterplot showing experimental purities of GateID predicted gates determined by scRNA-seq (x axis) and histological analysis (y axis) for HSPCs (dark blue) and monocytes (light blue) on BD FACSJazz (triangle) and BD FACSInflux (circle).

(H) Design of in silico reconstruction of the manual gate for lymphocyte enrichment. Cells from WKM TD2 are represented in gray and manual gate is drawn in red.

(I) Barplots indicating cell type percentages for the lymphocyte in silico manual gate. Percentage in the barplot indicates lymphocyte percentage in the in silico manual gate.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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Reprinted from Cell, 179, Baron, C.S., Barve, A., Muraro, M.J., van der Linden, R., Dharmadhikari, G., Lyubimova, A., de Koning, E.J.P., van Oudenaarden, A., Cell Type Purification by Single-Cell Transcriptome-Trained Sorting, 527-542.e19, Copyright (2019) with permission from Elsevier. Full text @ Cell