FIGURE

Fig. S6

ID

ZDB-FIG-181024-16

Publication

Xu et al., 2018 - Fox proteins are modular competency factors for facial cartilage and tooth specification

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Fig. S6

Expression of foxc1a in sox9a mutants and chondrocyte defects in Fox-C mutants

(A) Expression of foxc1a in the first two arches is unchanged in sox9a mutants at 42hpf.

(B) Confocal imaging of chondrocytes labeled by col2a1:mCherry-NTR (red) and osteoblasts labeled by sp7:GFP (green) at 72 hpf. In foxc1a; foxc1b mutants, col2a1:mCherry-NTR expression is weaker and/or reduced in the palatoquadrate (Pq), symplectic (Sy), and hyosymplectic (Hm) domains. sp7:GFP+ osteoblasts of the developing opercular bone (Op, arrows) are less affected. Numbers indicate proportion of animals showing the displayed patterns. Scale bars = 100 ?m.

Expression Data

Genes:	EGFP foxc1a mCherry
Fish:	WT sox9a^tw37/tw37 b1212Tg; el559Tg foxc1a^el543/el543; foxc1b^el620/el620; b1212Tg; el559Tg
Anatomical Terms:	hyosymplectic cartilage chondrocyte opercle osteoblast palatoquadrate cartilage chondrocyte pharyngeal arch 1 pharyngeal arch 2 symplectic chondrocyte (all 6)
Stage Range:	High-pec to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	foxc1a^el543/el543; foxc1b^el620/el620 foxc1a^el543/el543; foxc1b^el620/el620; b1212Tg; el559Tg foxf1^el658/el658; foxf2a^el616/el616; foxf2b^el621/el621
Observed In:	hyosymplectic cartilage chondrocyte palatoquadrate cartilage chondrocyte pectoral fin skeleton symplectic chondrocyte
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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