FIGURE

Fig. 2

ID

ZDB-FIG-180620-53

Publication

Sun et al., 2018 - CFTR mutation enhances Dishevelled degradation and results in impairment of Wnt-dependent hematopoiesis

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Fig. 2

Cftr critically regulates hematopoiesis in zebrafish.

a cftr mutants show hematopoietic defects at 8-somite stage (13 hpf). Embryos shown are dorsal views with anterior oriented at the top. b cftr mutants show hematopoietic defects at later stages. Embryos shown are lateral views with anterior to the left. Bottom panel: cftr mutants displayed decreased hemoglobin staining by O-dianisidine. Embryos shown are ventral views with anterior to the left. Arrowheads indicate the expression sites of each marker gene. All genes were assayed by WISH. Histogram representing the relative expression detected by signal strength grayscale using software ImageJ at corresponding assay. The percentage and numbers indicated in each picture are the ratio for the number (left in bracket) of affected embryos with phenotype similar to what is shown in the picture and the total number (right in bracket) of observed embryos. The same number labeling was used thereafter

Expression Data

Genes:	fli1 gata1a gata2a hbbe3 lmo2 myb runx1 spi1b tal1
Fish:	AB cftr^scu102/+
Anatomical Terms:	common myeloid progenitor erythroid lineage cell intermediate cell mass of mesoderm lateral plate mesoderm myeloid lineage restricted progenitor cell
Stage Range:	5-9 somites to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cftr^scu102/+
Observed In:	common myeloid progenitor erythroid lineage cell intermediate cell mass of mesoderm lateral plate mesoderm myeloid lineage restricted progenitor cell
Stage Range:	5-9 somites to Long-pec

Phenotype Detail

Acknowledgments

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