Gene

gata2a

ID

ZDB-GENE-980526-260

Name

GATA binding protein 2a

Symbol

gata2a Nomenclature History

Previous Names

gata2 (1)
gta2 (1)
zg2

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in animal organ development and dorsal aorta morphogenesis. Predicted to localize to nucleus. Is expressed in several structures, including hematopoietic system; mesoderm; nervous system; neural tube; and trunk vasculature. Human ortholog(s) of this gene implicated in acute myeloid leukemia; immunodeficiency 21; mental depression; myelodysplastic syndrome; and myeloid leukemia. Orthologous to human GATA2 (GATA binding protein 2).

Genome Resources

Note

None

Expression

All Expression Data

169 figures from 117 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

eu473 (20 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 17 figures from 9 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gata2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute myeloid leukemia	Alliance	{Leukemia, acute myeloid, susceptibility to}	601626
immunodeficiency 21	Alliance	Immunodeficiency 21	614172
myelodysplastic syndrome	Alliance	{Myelodysplastic syndrome, susceptibility to}	614286
		Emberger syndrome	614038

Associated With gata2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000679	Zinc finger, GATA-type
Family	IPR016374	Transcription factor, GATA-2/3
Family	IPR029522	Transcription factor GATA-2
Family	IPR039355	Transcription factor GATA
Homologous_superfamily	IPR013088	Zinc finger, NHR/GATA-type

Domain Details Per Protein

Protein	Length	Transcription factor GATA	Transcription factor GATA-2	Transcription factor, GATA-2/3	Zinc finger, GATA-type	Zinc finger, NHR/GATA-type
UniProtKB:Q7T3G1 InterPro	456
UniProtKB:Q90411 InterPro	194
UniProtKB:O42355 InterPro	10
UniProtKB:A0A2R9YJP8 InterPro	460
UniProtKB:A0A0R4IKY6 InterPro	116

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	gata2a-202 (1) Ensembl	2533 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	gata2a-203 (1) Ensembl	781 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Addgene:132977

Constructs

Marker Relationships

Sequences

Orthology

Gene Tree: Ensembl

Citations