Gene
gata2a
- ID
- ZDB-GENE-980526-260
- Name
- GATA binding protein 2a
- Symbol
- gata2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell fate commitment; positive regulation of angiogenesis; and positive regulation of pri-miRNA transcription by RNA polymerase II. Acts upstream of or within animal organ development and dorsal aorta morphogenesis. Predicted to be located in nucleus. Is expressed in several structures, including hematopoietic system; mesoderm; nervous system; neural tube; and trunk vasculature. Human ortholog(s) of this gene implicated in acute myeloid leukemia; immunodeficiency 21; mental depression; myelodysplastic syndrome; and myeloid leukemia. Orthologous to human GATA2 (GATA binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 171 figures from 119 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu473 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 10 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute myeloid leukemia | Alliance | {Leukemia, acute myeloid, susceptibility to} | 601626 |
| immunodeficiency 21 | Alliance | Immunodeficiency 21 | 614172 |
| myelodysplastic syndrome | Alliance | {Myelodysplastic syndrome, susceptibility to} | 614286 |
| Emberger syndrome | 614038 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Transcription factor GATA | Transcription factor GATA-2 | Transcription factor, GATA-2/3 | Zinc finger, GATA-type | Zinc finger, NHR/GATA-type |
|---|---|---|---|---|---|---|
|
UniProtKB:Q90411
|
194 | |||||
|
UniProtKB:Q7T3G1
|
456 | |||||
|
UniProtKB:A0A2R9YJP8
|
460 | |||||
|
UniProtKB:O42355
|
10 | |||||
|
UniProtKB:A0A0R4IKY6
|
116 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
gata2a-202
(1)
|
2533 nt | |
| mRNA |
gata2a-203
(1)
|
781 nt |
Interactions and Pathways
No data available
Plasmids