Gene

gata2a

ID
ZDB-GENE-980526-260
Name
GATA binding protein 2a
Symbol
gata2a Nomenclature History
Previous Names
  • gata2 (1)
  • gta2 (1)
  • zg2
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in animal organ development and dorsal aorta morphogenesis. Predicted to localize to nucleus. Is expressed in several structures, including hematopoietic system; mesoderm; nervous system; neural tube; and trunk vasculature. Human ortholog(s) of this gene implicated in acute myeloid leukemia; immunodeficiency 21; mental depression; myelodysplastic syndrome; and myeloid leukemia. Orthologous to human GATA2 (GATA binding protein 2).
Genome Resources
Note
None
Expression
All Expression Data
169 figures from 117 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
17 figures from 9 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gata2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute myeloid leukemia Alliance {Leukemia, acute myeloid, susceptibility to} 601626
immunodeficiency 21 Alliance Immunodeficiency 21 614172
myelodysplastic syndrome Alliance {Myelodysplastic syndrome, susceptibility to} 614286
Emberger syndrome 614038
Associated With gata2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000679 Zinc finger, GATA-type
Family IPR016374 Transcription factor, GATA-2/3
Family IPR029522 Transcription factor GATA-2
Family IPR039355 Transcription factor GATA
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Domain Details Per Protein
Protein Length Transcription factor GATA Transcription factor GATA-2 Transcription factor, GATA-2/3 Zinc finger, GATA-type Zinc finger, NHR/GATA-type
UniProtKB:Q7T3G1 456
UniProtKB:Q90411 194
UniProtKB:O42355 10
UniProtKB:A0A2R9YJP8 460
UniProtKB:A0A0R4IKY6 116
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations