ZFIN Gene: gata2a

ZFIN ID: ZDB-GENE-980526-260

ZFIN ID: ZDB-GENE-980526-260

Gene Name:

GATA binding protein 2a

Gene Symbol:

gata2a

Sequence Ontology ID :

SO:0000704

Previous Names:

gata2 (1), gta2 (1), zg2

Location:

Chr: 11 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have DNA-binding activity transcription factor activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity; involved in several ...

GENE EXPRESSION
All Expression Data:	161 figures from 112 publications
Directly Submitted Expression Data:	6 figures (20 images) from Thisse et al., 2005 [eu473]
Wild-type Stages, Structures:	Cleavage:64-cell (2.0h-2.25h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
	anatomical structure angioblastic mesenchymal cell anterior lateral plate mesoderm axial vasculature basal plate midbrain region blood island brain cranial ganglion DEL diencephalon dorsal aorta ectoderm dorsal region ectoderm ventral region ectoderm epiblast non neural ectoderm epiblast erythroid lineage cell hematopoietic multipotent progenitor cell hematopoietic system hindbrain intermediate cell mass of mesoderm hematopoietic stem cell intermediate cell mass of mesoderm intersegmental vessel Kolmer-Agduhr neuron medial region Kolmer-Agduhr neuron ventral-most region Kolmer-Agduhr neuron ventro-medial region lateral floor plate GABAergic neuron lateral floor plate Kolmer-Agduhr neuron lateral mesoderm lateral plate mesoderm neural tube neuron non neural ectoderm ventral region non neural ectoderm optic tectum otic vesicle pharyngeal arch posterior cardinal vein posterior lateral mesoderm posterior lateral plate mesoderm presumptive blood presumptive ectoderm retina rostral blood island spinal cord Kolmer-Agduhr neuron spinal cord interneuron superior cervical ganglion tegmentum trunk trunk ganglion trunk vasculature unspecified vascular endothelium VeLD dorsal region VeLD ventral region VeLD ventral mesoderm ventral wall of dorsal aorta ventricular zone whole organism anterior region whole organism ventral margin whole organism ventral region whole organism ventral side whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
um27	Small Deletion	Unknown	Frameshift, Premature Stop	ZINC_FINGER_NUCLEASE

Targeting reagents:

PHENOTYPE

Data:

17 figures from 9 publications

Observed in:

DISEASE ASSOCIATED WITH gata2a HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
acute myeloid leukemia	{Leukemia, acute myeloid, susceptibility to}	601626
myelodysplastic syndrome	{Myelodysplastic syndrome, susceptibility to}	614286
	Immunodeficiency 21	614172
	Emberger syndrome	614038

DISEASE ASSOCIATED WITH gata2a VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	primitive hemopoiesis (more)
Cellular Component	nucleus (more)
Molecular Function	DNA-binding transcription factor activity (more)

GO Terms (all 21)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR000679 (1) InterPro:IPR013088 (1) InterPro:IPR016374 (1) InterPro:IPR029522 (1) InterPro:IPR039355 (1)	PROSITE:PS00344 (1) PROSITE:PS50114 (1)	Pfam:PF00320 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	gata2a-202 (1)	2533	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	gata2a-203 (1)	781	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Withdrawn Transcripts
ncRNA	gata2a-002 (1)	1381	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM gata2a

MARKER RELATIONSHIPS

gata2aContained in:	[BAC] CH211-63I20 (1) (order this)
gata2aEncodes:	[EST] eu473 (1) [cDNA] MGC:63885 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131233 (1)	2571bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:AL928619 (1)	158847bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A2R9YJP8 (1)	460aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:356 (1)

Sequence Information (all 25)

OTHER gata2a GENE PAGES

Alliance (1)

Gene:30480 (1)

VEGA:OTTDARG00000020332 (1)

Ensembl(GRCz11):ENSDARG00000059327 (2)

ORTHOLOGY for gata2a (Chr: 11)

CITATIONS (304)

{{control.fieldName}} Edit

Attributions

Add new Alias

Attributions for Alias: {{control.newAlias}}

Delete Alias: