Gene
gata2a
- ID
- ZDB-GENE-980526-260
- Name
- GATA binding protein 2a
- Symbol
- gata2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within circulatory system development; hemopoiesis; and ventral spinal cord interneuron differentiation. Predicted to be active in nucleus. Is expressed in several structures, including hematopoietic system; mesoderm; nervous system; presumptive structure; and trunk vasculature. Human ortholog(s) of this gene implicated in acute myeloid leukemia; depressive disorder; immunodeficiency 21; myelodysplastic syndrome; and myeloid leukemia. Orthologous to human GATA2 (GATA binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 179 figures from 127 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu473 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute myeloid leukemia | Alliance | {Leukemia, acute myeloid, susceptibility to} | 601626 |
| immunodeficiency 21 | Alliance | Immunodeficiency 21 | 614172 |
| myelodysplastic syndrome | Alliance | {Myelodysplastic syndrome, susceptibility to} | 614286 |
| Emberger syndrome | 614038 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Transcription factor GATA | Transcription factor, GATA-2/3 | Zinc finger, GATA-type | Zinc finger, NHR/GATA-type |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q709 | InterPro | 397 | ||||
| UniProtKB:Q7T3G1 | InterPro | 456 | ||||
| UniProtKB:A0A8M3AXB8 | InterPro | 460 | ||||
| UniProtKB:A0AB32U358 | InterPro | 393 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gata2a-201
(1)
|
Ensembl | 2,829 nt | ||
| mRNA |
gata2a-202
(1)
|
Ensembl | 2,533 nt | ||
| mRNA |
gata2a-203
(1)
|
Ensembl | 781 nt |
Interactions and Pathways
No data available
Plasmids