Gene

gata2a

ID
ZDB-GENE-980526-260
Name
GATA binding protein 2a
Symbol
gata2a Nomenclature History
Previous Names
  • gata2 (1)
  • gta2 (1)
  • zg2
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in animal organ development and dorsal aorta morphogenesis. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia; mental depression; myelodysplastic syndrome; myeloid leukemia; and primary immunodeficiency disease. Is expressed in several structures, including hematopoietic system; mesoderm; nervous system; neural tube; and trunk vasculature. Orthologous to human GATA2 (GATA binding protein 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
177 figures from 125 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
18 figures from 10 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gata2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Emberger syndrome 614038
Immunodeficiency 21 614172
{Leukemia, acute myeloid, susceptibility to} 601626
{Myelodysplastic syndrome, susceptibility to} 614286
Associated With gata2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000679 Zinc finger, GATA-type
Family IPR016374 Transcription factor, GATA-2/3
Family IPR039355 Transcription factor GATA
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Domain Details Per Protein
Protein Length Transcription factor GATA Transcription factor, GATA-2/3 Zinc finger, GATA-type Zinc finger, NHR/GATA-type
UniProtKB:A0A8M9Q709 397
UniProtKB:Q7T3G1 456
UniProtKB:A0A8M3AXB8 460
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations