FIGURE

Fig. 5

ID

ZDB-FIG-180119-22

Publication

Schwarzer et al., 2017 - Dlx3b/4b is required for early-born but not later-forming sensory hair cells during zebrafish inner ear development

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Fig. 5

Analysis of upstream regulators of sensory hair cell and otolith development. (A-D) At OEPD (five somites) and placodal stages (12 somites), otic expression of atoh1b is absent in dlx3b/4b mutant embryos in comparison with wild-type siblings. (E,F) In contrast, atoh1b can be detected in dlx3b/4b mutants at 24 hpf although limited to the anterior portion of the otic vesicle. (G-J) Similarly, atoh1a is initially not expressed in the developing otic placode of dlx3b/4b-deficient embryos but present in the future domain of the utricular macula at 24 hpf. (K-N) Compared with wild-type control, otog expression is undetectable in dlx3b/4b mutants at placodal stages and restricted to the prospective domain of the utricular macula at 24 hpf. (A-D,G,H) Dorsolateral views with anterior to the left. (E,F,I,J) Lateral views with anterior to the left. OP, otic placode. Scale bar: 40 µm.

Expression Data

Genes:	atoh1a atoh1b otog
Fish:	AB Df(Chr12:dlx3b, dlx4b)tud70/tud70 (AB)
Anatomical Terms:	macula utricle otic placode otic vesicle
Stage Range:	5-9 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	Df(Chr12:dlx3b, dlx4b)tud70/tud70 (AB)
Observed In:	otic placode
Stage Range:	5-9 somites to 10-13 somites

Phenotype Detail

Acknowledgments

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