Gene
otog
- ID
- ZDB-GENE-120228-1
- Name
- otogelin
- Symbol
- otog Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have alpha-L-arabinofuranosidase activity and structural molecule activity. Involved in otolith formation and otolith tethering. Is expressed in otic vesicle and vestibuloauditory system. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 18B. Orthologous to human OTOG (otogelin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 26 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 18B | Alliance | Deafness, autosomal recessive 18B | 614945 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001007 | VWFC domain |
| Domain | IPR001846 | von Willebrand factor, type D domain |
| Domain | IPR002919 | Trypsin Inhibitor-like, cysteine rich domain |
| Domain | IPR006207 | Cystine knot, C-terminal |
| Domain | IPR007934 | Alpha-L-arabinofuranosidase B, arabinose-binding domain |
| Domain | IPR014853 | VWF/SSPO/Zonadhesin-like, cysteine-rich domain |
| Family | IPR050780 | Mucin/von Willebrand/Thrombospondin superfamily |
| Homologous_superfamily | IPR036084 | Serine protease inhibitor-like superfamily |
| Homologous_superfamily | IPR036195 | Alpha-L-arabinofuranosidase B, arabinose-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Alpha-L-arabinofuranosidase B, arabinose-binding domain | Alpha-L-arabinofuranosidase B, arabinose-binding domain superfamily | Cystine knot, C-terminal | EGF-like domain | Mucin/von Willebrand/Thrombospondin superfamily | Serine protease inhibitor-like superfamily | Trypsin Inhibitor-like, cysteine rich domain | von Willebrand factor, type D domain | VWFC domain | VWF/SSPO/Zonadhesin-like, cysteine-rich domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q1V8
|
3214 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance