ZFIN ID: ZDB-FIG-161027-16
Cox et al., 2016 - Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America   113(38):E5562-71 Full text @ Proc. Natl. Acad. Sci. USA
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Condition:
Observed In:
Stage: Adult

Fig. 6

seph genetically interacts with p53 deficiency to accelerate GI tumor formation. (A) Scheme illustrating the protocol used to study DMBA-induced tumorigenesis. (B) Example of a GI tumor in a tp53-/-;seph+/- fish exposed to DMBA. (Scale bar: 2 mm.) (C) Kaplan-Meier analysis of Tumor-free survival in tp53-/- and tp53-/-;seph+/- fish exposed to DMBA. n > 25 fish. P = 0.0344, Mantel-Cox log-rank test. (D) The incidence of pancreatic cancer, liver cancer, intestinal cancer, and malignant spindle cell neoplasm in tp53-/- and tp53-/-;seph+/- fish exposed to DMBA. (E) Histological evaluation of GI tumors identified in tp53-/-;seph+/- fish showing examples of PACC, HCC, and malignant spindle cell neoplasm (MSCN). (Scale bar: 100 ┬Ám.)

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
tp53zdf1/zdf1; selenohhi2737Tg/+ chemical treatment: 7,12-dimethyltetraphene Adult digestive system hepatocellular carcinoma increased amount, abnormal
Adult digestive system spindle cell sarcoma present, abnormal
Adult pancreas Acinar adenocarcinoma present, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Proceedings of the National Academy of Sciences of the United States of America for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Proc. Natl. Acad. Sci. USA