ZFIN ID: ZDB-IMAGE-161027-11
Figures for Cox et al., 2016

Figure Caption/Comments:

Fig. 6

seph genetically interacts with p53 deficiency to accelerate GI tumor formation. (A) Scheme illustrating the protocol used to study DMBA-induced tumorigenesis. (B) Example of a GI tumor in a tp53-/-;seph+/- fish exposed to DMBA. (Scale bar: 2 mm.) (C) Kaplan-Meier analysis of Tumor-free survival in tp53-/- and tp53-/-;seph+/- fish exposed to DMBA. n > 25 fish. P = 0.0344, Mantel-Cox log-rank test. (D) The incidence of pancreatic cancer, liver cancer, intestinal cancer, and malignant spindle cell neoplasm in tp53-/- and tp53-/-;seph+/- fish exposed to DMBA. (E) Histological evaluation of GI tumors identified in tp53-/-;seph+/- fish showing examples of PACC, HCC, and malignant spindle cell neoplasm (MSCN). (Scale bar: 100 ┬Ám.)

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