FIGURE

Fig. 2

ID

ZDB-FIG-151130-65

Publication

Faria et al., 2015 - Zebrafish Models for Human Acute Organophosphorus Poisoning

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Fig. 2

CPO induces concentration-dependent impairment of the retina architecture and the phototransduction pathways in zebrafish larvae.

Retinal histology (transverse plastic semithin sections) of representative control (A), grade 1 (B) grade 2 (C) and grade 3 (D) 8 days post fertilization zebrafish larvae shows a good relationship between the grade of the phenotype and the severity of the effects on the retinal architecture. (E) Heatmap of the phototransduction pathway (dre04744) in zebrafish control and grades 1, 2 and 3 larvae, showing a clear relationship between the grade of phenotype severity and the degree of down-regulation of this pathway. Abbreviations: GCL, ganglion cell layer; INL, inner nuclear layer; IPL, inner plexiform layer; ONL, outer nuclear layer; OPL; outer plexiform layer; RPE, retinal pigment epithelium. Scale bar: 100 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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