FIGURE

Fig. 1

ID

ZDB-FIG-151130-64

Publication

Faria et al., 2015 - Zebrafish Models for Human Acute Organophosphorus Poisoning

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Fig. 1

Chlorpyrifos-oxon (CPO) induces concentration-dependent inhibition of acetylcholinesterase (AChE) and the expression of three different phenotypes in zebrafish larvae.

(A) Concentration-response analysis of CPO regarding the inhibition of AChE activity and survival in zebrafish larvae exposed to different CPO concentrations from 7 to 8 days post fertilization (24 h exposure, 16 larvae per experimental group, p < 0.0001; AChE activity, F(1,143) = 1950.77, r² = 0.978; survival, F(1,59) = 251.295, r² = 0.9208). (B) Lateral views of representative 8 days post fertilization larvae control and the mild (grade 1), moderate (grade 2) and severe (grade 3) phenotypes. (C) Prevalence of the three different phenotypes in response to different CPO concentrations (48 larvae per experimental group). Scale bar: 1 mm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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