FIGURE

Fig. 5

ID

ZDB-FIG-150413-44

Publication

Jackson et al., 2015 - The role of Sox6 in zebrafish muscle fiber type specification

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Fig. 5

Partial de-repression of slow-twitch genes insox6mutant larvae. (A-C)smych1, tpm2 and mylz10 remain restricted to the slow-twitch fibers in wild-type larvae at 3 or 4 days postfertilization (dpf). (D-F) All three genes are ectopically expressed in some fast-twitch fibers in sox6 mutants by 3 or 4 dpf. (G-G′′)smyhc1:GFP expression (green) is excluded from fast-twitch fibers (red) in 5 dpf wild-type larvae. (H-H′′) In sox6 mutant larvae at 5 dpf, a subset of fast-twitch fibers ectopically express the reporter gene (H). The expression of the fast-twitch myosin revealed by mAb F310 (red) in the fast domain remains unaffected in sox6 mutants (cf G′ and H′).

Expression Data

Genes:	EGFP myl10 smyhc1 tpm2
Antibody:	Ab-F310
Fish:	WT sox6^i291/i291 i104Tg sox6^i291/i291; i104Tg
Anatomical Terms:	fast muscle cell slow muscle cell
Stage Range:	Protruding-mouth to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sox6^i291/i291 sox6^i291/i291; i104Tg
Observed In:	fast muscle cell
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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