Gene
tpm2
- ID
- ZDB-GENE-040625-114
- Name
- tropomyosin 2 (beta)
- Symbol
- tpm2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and muscle contraction. Located in striated muscle thin filament. Is expressed in adaxial cell; cardiovascular system; epiphysis; musculature system; and somite. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1A and nemaline myopathy 4. Orthologous to human TPM2 (tropomyosin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb836 (16 images)
- IMAGE:6892450 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa18509 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 1 of 1
Show
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| distal arthrogryposis type 1A | Alliance | Arthrogryposis, distal, type 1A | 108120 |
| distal arthrogryposis type 1A | Alliance | Arthrogryposis, distal, type 2B4 | 108120 |
| nemaline myopathy 4 | Alliance | Congenital myopathy 23 | 609285 |
1 - 3 of 3
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | DNA repair protein XRCC4-like, C-terminal | Tropomyosin |
|---|---|---|---|---|
| UniProtKB:A0A8M2B1Q6 | InterPro | 284 | ||
| UniProtKB:A0A8M2B1K3 | InterPro | 284 | ||
| UniProtKB:A0A8M2B255 | InterPro | 248 | ||
| UniProtKB:A0A8M2B1Q8 | InterPro | 248 | ||
| UniProtKB:A0A8M2B2D1 | InterPro | 248 |
1 - 5 of 8 Show all
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available