Gene

tpm2

ID
ZDB-GENE-040625-114
Name
tropomyosin 2 (beta)
Symbol
tpm2 Nomenclature History
Previous Names
  • cb836 (1)
  • fj63f03
  • tpm4l (1)
  • wu:fj63f03
  • zgc:86810 (1)
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have actin filament binding activity. Predicted to be involved in actin filament organization and muscle contraction. Localizes to striated muscle thin filament. Is expressed in adaxial cell; cardiovascular system; epiphysis; musculature system; and somite. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1A and nemaline myopathy 4. Orthologous to human TPM2 (tropomyosin 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tpm2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
distal arthrogryposis Alliance Arthrogryposis, distal, type 1A 108120
distal arthrogryposis Alliance Arthrogryposis, distal, type 2B4 108120
distal arthrogryposis type 1A Alliance Arthrogryposis, distal, type 1A 108120
distal arthrogryposis type 1A Alliance Arthrogryposis, distal, type 2B4 108120
nemaline myopathy 4 Alliance CAP myopathy 2 609285
nemaline myopathy 4 Alliance Nemaline myopathy 4, autosomal dominant 609285
Associated With tpm2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR000533 Tropomyosin
Domain Details Per Protein
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations