Gene

smyhc1

ID
ZDB-GENE-030131-271
Name
slow myosin heavy chain 1
Symbol
smyhc1 Nomenclature History
Previous Names
  • smhc1 (1)
  • fb18g10
  • im:6897999
  • wu:fb18g10
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to enable ATP binding activity; actin filament binding activity; and cytoskeletal motor activity. Acts upstream of or within skeletal muscle thin filament assembly; slow-twitch skeletal muscle fiber contraction; and striated muscle myosin thick filament assembly. Predicted to be part of myosin complex. Is expressed in cardiovascular system; musculature system; paraxial mesoderm; and somite. Human ortholog(s) of this gene implicated in atrial heart septal defect (multiple); heart conduction disease (multiple); and intrinsic cardiomyopathy (multiple). Orthologous to human MYH6 (myosin heavy chain 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
108 figures from 50 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With smyhc1 Human Ortholog
No data available
Associated With smyhc1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR001609 Myosin head, motor domain
Domain IPR002928 Myosin tail
Domain IPR004009 Myosin, N-terminal, SH3-like
Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
Homologous_superfamily IPR027401 Myosin IQ motif-containing domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain Details Per Protein
Protein Length IQ motif, EF-hand binding site Kinesin motor domain superfamily Myosin head, motor domain Myosin IQ motif-containing domain superfamily Myosin, N-terminal, SH3-like Myosin S1 fragment, N-terminal Myosin tail P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q508P8 1938
UniProtKB:A0A2R8Q8V2 1943
UniProtKB:B3DK50 1938
UniProtKB:Q7T1B6 355
UniProtKB:Q503C6 749
UniProtKB:A0MQ61 1938
UniProtKB:A4IGA2 950
UniProtKB:A0A0R4INI3 1938
UniProtKB:A0A2R8Q7G9 1969
UniProtKB:B1WB81 942
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations