ZFIN ID: ZDB-FIG-150313-33
Huc-Brandt et al., 2014 - Zebrafish Prion Protein PrP2 Controls Collective Migration Process during Lateral Line Sensory System Development. PLoS One   9:e113331 Full text @ PLoS One
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Fish:
Knockdown Reagent:
Anatomical Term:
Stage: Long-pec
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage: Long-pec

Fig. 7

Decreased hair cell number of PLL neuromast in PrP2-MO.

A–C. In control embryos at 48 hpf, Brn3-GFP fluorescence labels hair cells of neuromasts and ear. High magnification of the first 3 neuromasts and zoom of the first neuromast show 8 hair cells. D–F. Morphants displays reduced number of neuromasts. High magnification shows smaller hair cells number. G. Quantification indicates significant reduction of hair cells/neuromast, independently of the neuromast position (mean hair cell number: 5.5±0.4, n = 36, compare to control 7.9±0.2, n = 20, p<0.001).

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
GFP s356tTg control Long-pec posterior lateral line neuromast neuromast hair cell IFL
s356tTg + MO5-prnprs3 standard conditions Long-pec posterior lateral line neuromast neuromast hair cell IFL
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
s356tTg + MO5-prnprs3 standard conditions Long-pec posterior lateral line neuromast hair cell differentiation decreased occurrence, abnormal
Long-pec posterior lateral line neuromast has fewer parts of type neuromast hair cell, abnormal
Acknowledgments:
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