ZFIN ID: ZDB-FIG-150313-31
Huc-Brandt et al., 2014 - Zebrafish Prion Protein PrP2 Controls Collective Migration Process during Lateral Line Sensory System Development. PLoS One   9:e113331 Full text @ PLoS One
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Fish:
Knockdown Reagent:
Anatomical Term:
Stage: Prim-15
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage: Prim-15

Fig. 5

Loss of cell-cell contact and disorganization of collective migration of the primordium.

Select time points from time-lapse recording of primordium migration in claudinB-GFP embryos. In control embryos, primordium migration is continuous, with a neuromast deposition (time point 2h30) and out of view at the time point 4h30 (not shown). In contrast in one PrP2 morphant example, representative of the observed phenotypes, primordium migration shows a progressive rounded shape and arrest. See also Movies S6 and S7.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
EGFP zf106Tg control Prim-15 posterior lateral line primordium IFL
zf106Tg + MO5-prnprs3 standard conditions Prim-15 posterior lateral line primordium IFL
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
zf106Tg + MO5-prnprs3 standard conditions Prim-15 posterior lateral line neuromast primordium migration arrested, abnormal
Prim-15 posterior lateral line primordium circular, abnormal
Acknowledgments:
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