FIGURE

Fig. 7

ID

ZDB-FIG-150309-12

Publication

Superina et al., 2014 - Analysis of maternal-zygotic ugdh mutants reveals divergent roles for HSPGs in vertebrate embryogenesis and provides new insight into the initiation of left-right asymmetry

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Fig. 7

MZjek mutants show left–right patterning defects despite having intact embryonic midlines. (A–D) WISH for lefty1,2 (A,C; N=80,116) and spaw (B,D; N=16,43) in wildtype and MZjek embryos at 21 SS. (E) Percentage of embryos displaying left, right, bilateral and absent lefty1,2 and spaw expression in 20–22 SS wildtype (wt) and MZjek mutant embryos. (F–K) Midline markers shh (F,I), ntl (G,J), and lefty1 (H,K) are expressed continuously along the embryonic axis in both wildtype and MZjek embryos, indicating an intact midline.

Expression Data

Genes:	lft1 lft2 shha spaw tbxta
Fish:	WT ugdh^m310/m310
Anatomical Terms:	floor plate lateral plate mesoderm lateral plate mesoderm left side lateral plate mesoderm right side notochord
Stage:	20-25 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ugdh^m310/m310
Observed In:	determination of left/right asymmetry in lateral mesoderm
Stage:	20-25 somites

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 387(2), Superina, S., Borovina, A., and Ciruna, B., Analysis of maternal-zygotic ugdh mutants reveals divergent roles for HSPGs in vertebrate embryogenesis and provides new insight into the initiation of left-right asymmetry, 154-166, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.