ZFIN ID: ZDB-GENE-030219-1
Gene Name: southpaw
Gene Symbol: spaw    Nomenclature History

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Previous Names: ndr3 (2), unm s457, unm t30973, unm_s457, unm_t30973

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have cytokine activity; transforming growth factor beta receptor binding activity; and type I activin receptor binding activity. Involved in determination of left/right symmetry; embryonic heart tube left/right pattern formation; and regulation of BMP signaling pathway involved in heart jogging. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in visceral heterotaxy. Is expressed in several structures, including anterior neural rod; heart primordium; intermediate cell mass of mesoderm; mesoderm; and tail bud. Orthologous to human NODAL (nodal growth differentiation factor).
Genome Resources: Alliance (1),  Gene:338101 (1),  Ensembl(GRCz11):ENSDARG00000014309 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a205 Small Deletion Exon 1 Frameshift CRISPR
s457 Point Mutation Unknown Start Loss ENU
sa177 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9063 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t30973 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-spaw
    2
    CRISPR2-spaw 1
    CRISPR3-spaw 1
    MO1-spaw N/A 20
    MO2-spaw N/A 10
    MO3-spaw N/A 2
    PHENOTYPE
    Data: 31 figures from 20 publications
    Observed in:
    DISEASE ASSOCIATED WITH spaw HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH spaw VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    anxiety disorder zf105Tg/zf105Tg + MO1-spaw standard conditions Facchin et al., 2015
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of left/right asymmetry in lateral mesoderm (more)
    Cellular Component extracellular region (more)
    Molecular Function protein binding (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001111 TGF-beta, propeptide
    Domain IPR001839 Transforming growth factor-beta, C-terminal
    Family IPR015615 Transforming growth factor-beta-related
    Conserved_site IPR017948 Transforming growth factor beta, conserved site
    Homologous_superfamily IPR029034 Cystine-knot cytokine
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA spaw-201 (1)    Ensembl 1263
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM spaw No data available
    MARKER RELATIONSHIPS
    spaw Contained in: [BAC] CH211-173B16 (1)
    spaw Encodes: [cDNA] MGC:194178 (1), MGC:194213 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_180967 (1) 1229 bp
    Genomic GenBank:CT033825 (1) 152404 bp
    Select Tool
    Polypeptide UniProtKB:F1QX69 (1) 411 aa
    Sequence Information (all 13)
    ORTHOLOGY for spaw ( Chr: 5 )
    CITATIONS (218)