FIGURE

Fig. 5

ID

ZDB-FIG-140902-114

Publication

Li et al., 2014 - Zebrafish Adar2 Edits the Q/R Site of AMPA Receptor Subunit gria2alpha Transcript to Ensure Normal Development of Nervous System and Cranial Neural Crest Cells

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Fig. 5

Gene expression in neural tube and migratory neural crest.

(A, B) Embryos are under lateral view. (A) Expressions of brain regionalization genes. Expression of fgf8, krox20, and pax6a appear normal in the 24 hpf hypo-Q/R-editing morphants. (B, C) Expressions of neural crest genes. The expression of mesenchymal condensations marker, sox9a, in the pharyngeal arch (pa, *) are slightly but consistently reduced in the hypo-Q/R-editing morphants. Expressions of neural crest markers foxd3 and crestin are mildly affected at 6-somite and 16-somite stages. Anterior is respectively to the left and top at lateral and dorsal views. 1, 2 and 3 are the three migration cranial neural crest streams originated from posterior mesencephalon and hindbrain. Arrows indicate the midbrain hindbrain boundary. e, eye; hb, f, forebrain, hb, hindbrain; r2 and r4, rhombomeres 2 and 4.

Expression Data

Genes:	crestin egr2b fgf8a foxd3 pax6a sox9a
Fish:	WT WT + MO1-adarb1a WT + MO1-gria2a WT + MO2-adarb1a
Knockdown Reagents:	MO1-adarb1a MO1-gria2a MO2-adarb1a
Anatomical Terms:	forebrain hindbrain midbrain hindbrain boundary neural crest pharyngeal arch rhombomere
Stage Range:	5-9 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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